Tuesday, 11 June 2013

Master regulator in cancer metastasis discovered

June 10, 2013 ? The predominant cause of death in cancer patients is metastasis, the formation of secondary tumors in other organs like the brain, liver, and lungs. Cancer cells detach from the original primary tumor and reach a single cell or group of cells in another organ. The cells of the body normally remain in place through adhering to an extracellular substance. However, cancer cells learn how to release themselves from these bonds and invade surrounding tissues, blood, and the lymphatic system.

The transformation of sedentary, specialized cells into wandering, invasive, and unspecialized cells is called epithelial-mesenchymal transition (EMT), which is central to metastasis. EMT is a multistage process, which is accompanied by a fundamental change in cell morphology and number of genetic programs. The molecular processes that govern EMT, however, are still poorly understood.

Main Switch Found

The research groups of Prof. Gerhard Christofori of the Department of Biomedicine at the University of Basel; Prof. Erik van Nimwegen from the Biozentrum, University of Basel; and Prof. Dirk Schuebeler from the Friedrich Miescher Institute have discovered a master regulator of EMT and metastasis: the transcription factor Sox4 is upregulated in its activity and triggers the expression of a number of genes that play an important role during EMT and metastasis.

In particular, Sox4 promotes the expression of the enzyme Ezh2, a methyltransferase, which generally influences methylation of specific proteins (histones), the packaging of the genetic material, and thus its readability and gene expression. Due to this change in genetic information, the behavior and function of cells are reprogrammed -- a process that is currently observed during metastasis. Such a change in gene expression is also found in patients with malignant cancer and metastasis and correlates with a poor prognosis.

These findings point to the possibility that the inhibition of the transcription factor Sox4 and especially the methyltransferase Ezh2 could hinder metastasis in cancer patients. Appropriate medications are currently being developed but they need to undergo clinical trials before being used in patients. The research was implemented within the framework of the SystemsX.ch-RTD Project "Cell Plasticity."

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Story Source:

The above story is reprinted from materials provided by University of Basel, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Neha Tiwari, Vijay?K. Tiwari, Lorenz Waldmeier, Piotr?J. Balwierz, Phil Arnold, Mikhail Pachkov, Nathalie Meyer-Schaller, Dirk Sch?beler, Erik van?Nimwegen, Gerhard Christofori. Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming. Cancer Cell, 2013; 23 (6): 768 DOI: 10.1016/j.ccr.2013.04.020

Note: If no author is given, the source is cited instead.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/HLFYOOLSwUA/130610133123.htm

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Monday, 10 June 2013

Japan PM Abe unveils plan for tax cuts to boost capex

TOKYO (Reuters) - Japanese Prime Minister Shinzo Abe said on Sunday the government would decide on tax cuts in autumn to encourage companies to boost capital expenditure as part of sweeping reforms to revive the economy from nearly two decades of stagnation.

The government will also work on legislation to scrap regulations hampering corporate research and investment and secure passage in parliament in autumn, he said.

"We'd like to decide on bold tax cuts for capital expenditure in autumn," Abe told public broadcaster NHK.

The measures will add to a series of steps the government unveiled in a draft of its growth strategy last week, such as setting up special economic zones to attract foreign business and raising incomes by 3 percent annually.

The growth strategy is the "Third Arrow" in Abe's prescription to reverse deflation, which also includes hyper-easy monetary policy and big government spending.

The first part of Abe's growth strategy, to be finalized on Friday, failed to impress markets that saw it as lacking specifics. That helped push down Japanese equities to two-month lows on Friday.

Abe said his government would lay out the second part of his growth strategy in autumn, to include the tax cuts, when parliament reconvenes after an upper house election on July 21.

"We will make that parliament session one in which we'll implement our growth strategies," he said.

On recent market turbulence and sharp falls in Tokyo share prices, Abe said he would not comment on day-to-day market moves, but stressed that his policy measures were already leading to improvements in output and job conditions.

(Reporting by Leika Kihara; Editing by Ron Popeski)

Source: http://news.yahoo.com/japan-pm-abe-unveils-plan-tax-cuts-boost-022730736.html

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Friday, 24 May 2013

The World's Smallest RC Helicopter Can Be Destroyed By a Fly Swatter

It was impressive enough when toymakers found a way to make remote control helicopters small and safe enough to fly around indoors. But their miniaturization efforts continue on as toymaker Silverlit introduces the Nano-Falcon, an RC chopper so tiny that Guinness has officially granted it the world record for smallest IR-controlled helicopter.

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/t7T4Dq0b2Gg/the-worlds-smallest-rc-helicopter-can-be-destroyed-by-509500268

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Thursday, 23 May 2013

Health Canada recalling novelty sets containing small, powerful magnets

Sheryl Ubelacker, The Canadian Press
Published Wednesday, May 22, 2013 2:01PM EDT

TORONTO -- Health Canada has issued a recall for a number of adult novelty products containing small, powerful magnets that can be swallowed or inhaled by children.

BuckyBalls novelty sets contain a number of rare earth element magnets many times more powerful than traditional magnets.

Some children have needed emergency surgery to remove swallowed magnets that can attract one another while moving through the intestines.

The magnets can trap intestinal tissue between them and cause life-threatening blockages or tearing.

Distributors of BuckyBalls are voluntarily recalling the products after a Health Canada risk assessment found they pose a danger to human health and safety.

The federal department says consumers should stop using the magnet sets and contact their municipality for instructions on safe disposal or recycling.

"Canadians expect that products they find on store shelves will be safe," Health Minister Leona Aglukkaq said in a statement Wednesday. "It's clear that some products containing small, powerful magnets pose a danger to children so we are taking action to have them removed from the marketplace."

The adult entertainment products typically involve puzzle working, sculpture building, mental stimulation or stress relief.

Online advisory: http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2013/31619a-eng.php

Source: http://www.ctvnews.ca/health/health-canada-recalling-novelty-sets-containing-small-powerful-magnets-1.1292206

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Small, speedy plant-eater extends knowledge of dinosaur ecosystems

May 22, 2013 ? Dinosaurs are often thought of as large, fierce animals, but new research highlights a previously overlooked diversity of small dinosaurs. In the Journal of Vertebrate Paleontology, a team of paleontologists from the University of Toronto, Royal Ontario Museum, Cleveland Museum of Natural History and University of Calgary have described a new dinosaur, the smallest plant-eating dinosaur species known from Canada. Albertadromeus syntarsus was identified from a partial hind leg, and other skeletal elements, that indicate it was a speedy runner. Approximately 1.6 m (5 ft) long, it weighed about 16 kg (30 lbs), comparable to a large turkey.

Albertadromeus lived in what is now southern Alberta in the Late Cretaceous, about 77 million years ago. Albertadromeus syntarsus means "Alberta runner with fused foot bones." Unlike its much larger ornithopod cousins, the duckbilled dinosaurs, its two fused lower leg bones would have made it a fast, agile two-legged runner. This animal is the smallest known plant-eating dinosaur in its ecosystem, and researchers hypothesize that it used its speed to avoid predation by the many species of meat-eating dinosaurs that lived at the same time.

Albertadromeus was discovered in 2009 by study co-author David Evans of the Royal Ontario Museum as part an on-going collaboration with Michael Ryan of the Cleveland Museum of Natural History to investigate the evolution of dinosaurs in the Late Cretaceous of North America. The known dinosaur diversity of this time period is dominated by large bodied plant-eating dinosaurs.

Why are so few small-bodied dinosaurs known from North America some 77 million years ago? Smaller animals are less likely to be preserved than larger ones, because their bones are more delicate and are often destroyed before being fossilized. "We know from our previous research that there are preservational biases against the bones of these small dinosaurs," said Caleb Brown of the University of Toronto, lead author of the study. "We are now starting to uncover this hidden diversity, and although skeletons of these small ornithopods are both rare and fragmentary, our study shows that these dinosaurs were more abundant in their ecosystems than previously thought."

The reason for our relatively poor understanding of these small dinosaurs is a combination of the taphonomic processes (those related to decay and preservation) described above, and biases in the way that material has been collected. Small skeletons are more prone to destruction by carnivores, scavengers and weathering processes, so fewer small animals are available to become fossils and smaller animals are often more difficult to find and identify than those of larger animals.

"Albertadromeus may have been close to the bottom of the dinosaur food chain but without dinosaurs like it you'd not have giants like T. rex," said Michael Ryan. "Our understanding of the structure of dinosaur ecosystems is dependent on the fossils that have been preserved. Fragmentary, but important, specimens like that of Albertadromeus suggest that we are only beginning to understand the shape of dinosaur diversity and the structure of their communities."

"You can imagine such small dinosaurs filling the niche of animals such as rabbits and being major, but relatively inconspicuous, members of their ecological community" said Anthony Russell of the University of Calgary.

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Story Source:

The above story is reprinted from materials provided by Society of Vertebrate Paleontology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Caleb Marshall Brown, David C. Evans, Michael J. Ryan, Anthony P. Russell. New data on the diversity and abundance of small-bodied ornithopods (Dinosauria, Ornithischia) from the Belly River Group (Campanian) of Alberta. Journal of Vertebrate Paleontology, 2013; 33 (3): 495 DOI: 10.1080/02724634.2013.746229

Note: If no author is given, the source is cited instead.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/eVEXRoxbwNA/130522142028.htm

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Kerry: US, allies, ready to step up aid rebels

AMMAN, Jordan (AP) ? The U.S. and several key allies sought Wednesday a strategy to end Syria's civil war, their united efforts unable at the moment to stem the Assad regime's military gains and Washington still unwilling to join those providing the rebels with lethal military aid.

U.S. Secretary of State John Kerry allowed that President Barack Obama won't send American troops to Syria. But he made clear that more aid to the rebels would be coming if the regime refuses to cooperate with an international effort ? to be put together in June in Geneva ? to form a transitional government.

"In the event that we can't find that way forward, in the event that the Assad regime is unwilling to negotiate Geneva in good faith, we will also talk about our continued support, growing support for opposition in order to permit them to continue to fight for the freedom of their country," Kerry said.

Obama "has also made it clear that he intends to support the broad-based opposition, and he has taken no options off the table with respect to how that support may be provided, or what kind of support that might be," he told a news conference with Jordanian Foreign Minister Nasser Judeh before a meeting between Kerry and the foreign ministers of 10 close American partners.

Wednesday's meeting comes after several weeks of military gains by the Assad regime, including the reopening of a key southern highway to Jordan and a push into a strategic rebel-held western town over the weekend.

Such successes will likely harden Assad's position in any peace talks. The Syrian leader has said that he will not step down as a result of transition talks, and that Syria's political future must be determined in elections.

Kerry and the other top diplomats met behind closed doors for more than two hours Wednesday evening in Amman to discuss how to change the momentum.

A Jordanian-based Western diplomat, who insisted on anonymity because he is not authorized to speak publicly on the matter, said the Assad regime was proving more resilient than expected. He said his government was concluding the rebels might not be able to defeat it without greater and more direct assistance.

Some of that new resilience in the Syrian regime comes from help from Iran and the militant Hezbollah movement.

Kerry warned those regime allies to stop providing assistance to Assad, saying such activity "perpetuates the regime's campaign of terror against its own people."

"We have to hope that Bashar Assad and his regime will understand the meaning of that and the Iranians and others will understand the meaning of that," Kerry said. "The president will keep those options available to him short of American forces on ground."

To that end, an administration official in Washington said the White House would soon notify Congress about an expanded package of non-lethal assistance to the Syrian rebels.

Details of the aid package are still being finalized, according to the official, who was not authorized to discuss the expanded aid publicly and insisted on anonymity.

But the package is likely to include armored vehicles and communications gear, two U.S. officials said. It is not expected to include night vision goggles or body armor, underscoring the cautious approach the U.S. has taken regarding military-style assistance to the opposition.

As Kerry and his counterparts arrived at the meeting venue in Amman, about 250 pro-Assad demonstrators blocked the main entrance.

The protesters, a mix of Jordanians and Syrians, chanted "Death to America," and, "Go home, Kerry we don't want you here."

A key battle has been waged since Sunday over control of the western town of Qusair, which had been in rebel hands for more than a year. Qusair is located along a land corridor that links two Assad strongholds, the capital Damascus and the heartland of Assad's Alawite sect along the Mediterranean coast.

Syrian troops backed by fighters from Lebanon's Shiite Muslim Hezbollah militia have pushed into Qusair since the start of the offensive. Underlining its importance, Syria's main opposition alliance, the Syrian National Coalition, on Wednesday urged rebel fighters from across Syria to converge on the town to help defend it.

Opposition fighters in Qusair were holding out Wednesday, but appeared to be under increasing strain as government tanks and artillery pounded the town and warplanes bombed it from the sky.

The battle for Qusair has also raised Hezbollah's profile in Syria's civil war. The Lebanese militia, one of Assad's staunchest allies, initially tried to play down its involvement to avoid political backlash at home, but could no longer do so after dozens of its fighters were killed in Qusair this week, followed by funerals drawing large crowds in Lebanon.

Most of Lebanon's Sunni Muslims back the Syria's predominantly Sunni opposition, while Shiites support the Assad regime, which is dominated by members of his minority Alawite sect, an off-shoot of Shiite Islam.

The battle in Qusair, six miles from the Lebanese border, was accompanied by new sectarian clashes in Lebanon's northern port city of Tripoli. Supporters and opponents of Assad have traded gunfire every day since Sunday, leaving 10 people dead and more than 100 wounded, Lebanese security officials said.

At the news conference, Kerry and Judeh both stressed that the goal is to get the Syrian government and opposition into political transition talks that could begin as early as next month in Geneva.

Without that, violence will continue and the death toll from the conflict will continue to rise, he said.

"Let's assume there is no Geneva 2," Kerry said. "Let's assume we don't come together as community of nations to try to find a peaceful process."

"What will happen? What will happen is an absolute guarantee that violence will continue and the world will be standing on the sidelines doing nothing constructive to try to end that violence. That's unacceptable," he said.

The comments came a day after a Senate panel voted to provide weapons to the rebels, the first time American lawmakers have endorsed the aggressive U.S. military step of arming the opposition.

With a degree of trepidation, the Foreign Relations Committee voted 15-3 for a bill that would provide lethal assistance and military training to vetted rebel groups, and would slap sanctions on anyone ??" such as Iran or Russia ??" who sells oil or transfers arms to the Assad regime. The measure would also establish a $250 million fund to aid in the transition if and when Assad falls.

___

Mroue reported from Beirut. Associated Press writers Julie Pace and Matthew Lee in Washington and Jamal Halaby in Amman contributed to this report.

Source: http://news.yahoo.com/kerry-us-allies-ready-step-aid-rebels-150432436.html

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Xbox One: All the Nerdy Details You Don't Know Yet

You saw the news yesterday. The Xbox One was everywhere, and everyone talked a lot about it. But when a new console hits, often we'll latch onto the biggest, shiniest new baubles. Now though, having slept on it, let's dig into the real nerd porn. It's worth a look.

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/ZGcTdr5z068/xbox-one-all-the-nerdy-details-you-dont-know-yet-509381624

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